Follow-up of adverse events after Roun-en-Y gastric bypass surgery in type 2 diabetic patients with different body mass index

Objective To investigate the incidence of adverse events in type 2 diabetic patients with different body mass indexes (BMI) after Roun-en-Y gastric bypass (RYGB) surgery. Methods From May 2010 to December 2017, a total of 100 patients with type 2 diabetes mellitus (T2DM) underwent laparoscopic RYGB in Daping Hospital. BMI, blood glucose, blood lipid, blood pressure and adverse events were followed-up before and after RYGB surgery. By using 27.5 kg/m2 of BMI as a cut-point, patients with BMI≥27.5 kg/m2 were as the high BMI group, and those BMI<27.5 kg/m2 were as the low BMI group. The outcome differences of metabolic indexes and the incidences of adverse events between these two groups were compared, and the corresponding treatment measures were reviewed. Data were analyzed by t test and analysis of variance, the rate of comparison was analyzed by χ2 test. Results At one year after surgery, BMI, glycosylated hemoglobin (HbA1c), serum total cholesterol (TC), serum triglyceride (TG), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were significantly decreased in the low BMI group (t=2.1-6.8, all P 0.05]. Nor was the incidence of anemia, zinc deficiency or hypoproteinemia, either (13.3% vs 13.3%, 25% vs 0, 0 vs 26.6%, 22.2% vs 14.2%, 13.3% vs 15.0%, 10% vs 0, χ2=0-2.9, all P>0.05). Furthermore, according to the number of adverse events at one year after surgery, patients with two kinds of adverse events had significant decrease in HbA1c (t=2.4, P<0.05), and patients with 3 or more kinds of adverse events had significant differences in FPG, HbA1c, TG, SBP and DBP (t=2.2-2.9, all P<0.05). Conclusion The short and long term effects of gastric bypass surgery on type 2 diabetic patients are significant. There is no significant correlation between postoperative adverse events and preoperative BMI in type 2 diabetic patients with RYGB surgery. Key words: Diabetes mellitus, type 2; Gastric bypass; Body mass index; Adverse events