5‐aminosalicylic acid interferes in the cell cycle of colorectal cancer cells and induces cell death modes
2010
Introduction:
Epidemiological data suggests that 5-aminosalicylic acid (5-ASA), a nonsteroidal antiinflammatory drug used in the treatment of inflammatory bowel diseases, prevents colorectal cancer development in these patients, although the mechanisms remain incompletely understood.
Methods and Results:
Here we report that 5-ASA prevents growth of several colorectal cancer cell lines by interfering in the cell cycle, i.e., an S-phase and G2/M phase arrest, dependent on 5-ASA dosage and concentration, together with an increased mitotic index. In addition, prolonged cell cycle arrest by repeated 5-ASA treatment induced apoptosis and caused abnormal spindle organization leading to mitotic catastrophe, another form of cell death.
Conclusion:
These observations illustrate that 5-ASA has chemopreventive and chemotherapeutic properties. (Inflamm Bowel Dis 2010;)
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