Synthesis, Antibacterial and Antitumor Activity of Semisynthetic Penicillins and Cephalosporins Based on New Sarcomycin Analogs

A series of new semisynthetic penicillins and cephalosporins containing structural fragments of the well-known antitumor antibiotic sarcomycin have been synthesized and their antitumor and antibacterial properties have been studied. The synthesized compounds showed substantial antitumor and antibacterial activities.