Targeted immunotherapy for Epstein-Barr virus: Positive central nervous system lymphoma in immunosuppressed patients.

e12529 Background: The occurrence of central nervous system (CNS) lymphoma in patients who have been treated with immunosuppressive therapy after organ transplantation or for chronic autoimmune disease, is rare. Most of these tumors are positive for Epstein-Barr virus (EBV). There is no standard therapy for this rare disease. Two patients are presented who developed isolated CNS lymphoma 12 years after renal transplant (Case #1) and 10 years after initiating imunosuppressive treatment for Sjorgren's syndrome (Case #2). They participated in a study specificly for post-transplant lymphocytic disorder (PTLD). Methods: Case #1 is a 56 year old female who underwent kidney transplant in 1990, serology was EBV positive. The kidney failed in 2001 and another transplant was performed. In Aug., 2004, a cervical cord B-cell lymphoma was diagnosed. The lesion was CD-20 positive, LMP1and EBNA 2 positive. Case #2 is a 63 year old female who developed confusion and aphasia in Feb., 2008. She was diagnosed with lt. parie...