Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice

Abstract A series of propiophenone derivatives ( 6 – 23 ) have been synthesized and evaluated for their in vivo antihyperglycemic activities in sucrose loaded model (SLM), sucrose challenged streptozotocin (STZ-S) induced diabetic rat model and C57BL/KsJ db / db diabetic mice model. Compound 15 and 16 were emerged as potent antihyperglycemics and lipid lowering agents. These compounds ( 15 , 16 ) further validate the potency by reducing body weight and food intake in db / db mice model. Possible mechanism of action for the propiophenone derivatives was established by the evaluation in various in vitro models. Interestingly some of the compounds were efficiently inhibiting PTP-1B.