Effect of fluid therapy with gelofusion on hemodynamics and oxygen metabolism in early acute respiratory distress syndrome

Objective To observe the heterogeneous response of hemodynamics and oxygen metabolism of piglets with acute respiratory distress syndrome (ARDS) caused by oleic acid injection to restrictive fluid therapy using colloid or crystalloid.Methods ARDS models were established by oleic acid injection of 12 piglets.The piglets were randomly treated by restrictive fluid therapy for 6 h guided by early goal-directed therapy (EGDT) using crystalloid (group A) or colloid (group B).The results of hemody-namics and oxygen metabolism were measured at different time points.Results After ARDS models were established,extravascular lung water (EVLW),lung compliance,and arterial oxygenation index got wors-en obviously in both groups.Group A wasted more time to reach the standard of EGDT and needed more liquid than group B.Afer the 6-h fluid therapy,central venous oxygen saturation (ScvO2),intramucosal pH (pHi),cardiac output (CO) and cardiac index (CI) in group B were higher than in group A.EVLW and arterial oxygenation index exhibited improvement in both groups,but there was no significant difference in EVLW and arterial oxygenation index between two groups.Conclusion Restrictive fluid therapy with colloid can obtain hemodynamic stability,improve oxygenation and reduce pulmonary interstitial edema,and has no difference to restrictive fluid therapy with crystalloid. Key words: Fluid therapy ;  Hemodynamics ;  Colloid;  Acute respiratory distress syndrome