Correlativity study on relationship between efficacy of adefovir dipvoxil and HBV genotypes in chronic hepatitis B

Objective To investigate the distribution of hepatitis B virus(HBV) genotypes and observe the response of different HBV genotypes to adefovir dipiroxil in antiviral treatment of chronic hepatitis B.Methods The alanine aminotransferase(ALT) level,HBV DNA quantum and HBV-M quantum of 285 cases with chronic hepatitis B(219 cases of genotype B named group B and 66 cases of genotype C named group C) were observed in 12,24,48 and 96 weeks after treatment with adefovir dipiroxil.Results After 12 weeks of adefovir dipivoxil therapy,HBV DNA negative conversion rate of genotype B and genotype C was 30.6%,36.4%,respectively.The mean HBV DNA reduction in patients with genotype B and genotype C was (1.36±0.98) copies/ml,(1.31±1.40) copies/ml(P0.05).After treatment for 24 weeks,HBV DNA negative conversion rate of genotype B and genotype C was 33.8% and 42.4%.The mean HBV DNA reduction in patients with genotype B and genotype C was(2.19±1.18) copies/ml,(2.22±1.10) copies/ml(P0.05).After 48 weeks of therapy,two genotypes' HBV DNA negative conversion rates were 38.8% and 45.5%.The mean HBV DNA reduction in patients with genotype B and genotype C was(2.98±1.24) copies/ml,(2.97±0.92) copies/ml(P0.05).After 96 weeks of therapy,HBV DNA negative conversion rate of two genotypes was 44.8% and 48.5%.The mean HBV DNA reduction in patients with genotype B and genotype C was(3.41±1.68) copies/ml,(3.50±1.72) copies/ml(P0.05).After 12 weeks' therapy,the HBeAg negative conversion rate of genotype B and genotype C was 10.6% vs 8.6%,while HBeAb occurrence was 11.6% vs 9.3%.After 24 weeks of therapy,HBeAg negative conversion rate of two genotypes was 14.6% vs 11.3%,while the HBeAb occurrence was 16.3% vs 11.6%.After 48 weeks of therapy,HBeAg negative conversion rate of two genotypes was 27.8% vs 21.2%,while HBeAb occurrence was 25.6% vs 20.9%.After 96 weeks of therapy,HBeAg negative conversion rate of two genotypes was 36.4% vs 25.2%,while the HBeAb occurrence was 39.5% vs 25.6%(P0.05).In genotype B and genotype C,ALT normalization rate after treatment for 12,24,48,96 weeks was 59.8% vs 47.0%,60.3% vs 63.6%,76.3% vs 77.3% and 80.0% vs 80.3%(P0.05).Conclusion The genotype of HBV B and C could have the same virologic and biochemical response to adefovir dipiroxil therapy,suggesting that HBV genotypes are not obviously relevant to the virological response of adefovir dipiroxil treatment.The prevalence HBV genotype is genotype B and C,there ware no genotype A and D found in Jiangxi province.