Severe Reactivation of Hepatitis B Virus Infection in a Patient with Hairy Cell Leukemia: Should Lamivudine Prophylaxis be Recommended to HBsAg-Negative, Anti-HBc-Positive Patients?
2006
The reverse seroconversion to hepatitis B virus infection has been sporadically described in onco-haematological patients receiving cytotoxic therapy or allogeneic bone marrow transplantation and can be associated with the development of acute icteric hepatitis. We present a male HBsAg-negative, anti-HBc-positive patient with Hairy Cell Leukemia who developed acute B hepatitis more than 1 year after the last course of 2-CdA and 6 months after splenectomy, while the patient was receiving therapy with αIFNr. The acute B hepatitis promptly responded to lamivudine therapy followed by viral clearance.
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