5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.

Patrick Angibaud,Xavier Bourdrez,Ann Devine,David End,Eddy Jean Edgard Freyne,Yannick Aimé Eddy Ligny,Philippe Muller,Geert Mannens,Isabelle Pilatte,Virginie Sophie Poncelet,Stacy Skrzat,Gerda Smets,Jacky Van Dun,Pieter Van Remoortere,Marc Venet,Walter Wouters

5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.

2003

Patrick Angibaud
Xavier Bourdrez
Ann Devine
David End
Eddy Jean Edgard Freyne
Yannick Aimé Eddy Ligny
Philippe Muller
Geert Mannens
Isabelle Pilatte
Virginie Sophie Poncelet
Stacy Skrzat
Gerda Smets
Jacky Van Dun
Pieter Van Remoortere
Marc Venet
Walter Wouters

Abstract The evaluation of structure–activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.

Keywords:

Farnesyltransferase
Farnesyl-diphosphate farnesyltransferase
Organic chemistry
Moiety
Structure–activity relationship
Lactam
Biochemistry
Enzyme inhibitor
Chemistry
Bicyclic molecule
Stereochemistry
tertiary amine
Chemical synthesis

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