Integration of terbium isotopes into modern nuclear medicine

The review examines the clinical role of terbium isotopes in the context of their integration into modern routine practice in nuclear medicine. Low toxicity, combined with an optimal half-life and elimination time from the body, makes them very promising not only in the therapeutic sense, but also in the issue of diagnostic imaging of tumors. When performing PET /CT and SPECT/CT imaging with 152Tb and 155Tb isotopes on cancer patients, high diagnostic information values were obtained. It should be noted that in the context of 152Tb, the phase of clinical trials on patients has already been completed, according to the results of which this radionuclide has demonstrated its potential. SPECT with 155Tb provides excellent imaging performance in mammals, even with low levels of injected radioactivity, which makes it promising for use in humans.