Chiral phosphine-catalyzed asymmetric [4+1] annulation of polar dienes with allylic derivatives: enantioselective synthesis of substituted cyclopentenes
2021
Abstract A chiral phosphine-catalyzed asymmetric [4+1] annulation reaction of polar 1,3-dienes and allylic derivatives is reported. Under the catalysis of P-chiral bicyclic phosphine (15 mol%), a series of 1,1-dicyano-2,4-diaryl-1,3-dienes (21 examples) readily undergo stereoselective [4+1] annulation reactions with allylic acetate under mild conditions, delivering enantio-enriched polysubstituted cyclopentenes in 49-89% yields and 51-98% ee. A plausible mechanism for the reaction is also discussed.
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