Gadobenate dimeglumine (MultiHance) or gadoterat emeglumine (Dotarem) for brain tumour imaging? An intra-individual comparison

Method and materials One hundred seventy-seven adult patients with suspected or known brain tumours were randomised to one of two study arms to undergo two identical exams at 1.5T, one with gadobenate at 0.1 (Arm 1; 70 patients) or 0.05 (Arm 2; 107 patients) mmol/kg bodyweight, and the other with gadoterate at 0.1 mmol/kg bodyweight. The agents were injected in randomised order separated by 2–14 days. Imaging sequences (T1SE and T1GRE) and acquisition timing were identical for the two exams. Three blinded readers evaluated images qualitatively for diagnostic information (lesion extent, delineation, morphology, enhancement, global preference) and quantitatively for % lesion enhancement and lesion-to-background ratio (LBR). Safety assessments were performed.