© 2012 Landes Bioscience. Do not distribute. NK cells sense tumors, course of disease and treatments Consequences for NK-based therapies

Keywords: NK cells, tumors, chemotherapyAbbreviations: ADCC, antibody dependent cell cytotoxicity; AML, acute myeloid leukemia;CML, Chronic Myeloid Leukemia; CRC, colorectal cancers; CTC, Circulating tumor cells; DC, Dendritic cell;EMT, epithelial-mesenchymal transition; GIST, gastrointestinal tumor; HIF, Hypoxia-inducible factor; HLA, human leukocyteantigen; HSCT, hematopoietic stem cell transplantation; ICAM-1, intracellular adhesion molecule-1; IFN, interferon;IM, Imatinib Mesylate; IRF, Interferon regulatory factor; IS, Immunological synapse; KIR, Killer Immunoglobulin-like receptor;LFA-1, lymphocyte function-associated antigen-1; LMP2, EBV-latent membrane protein 2; MICA/B, MHC-class-I-related Chain A/B;NK, natural killer cell; RCC, Renal cell carcinoma; STAT-1, Signal Transducer and Activator of Transcription factor-1;STRA-13, Stimulated by retinoic acid-13; VHL, Von Hippel Lindau