Pro-brain natriuretic peptide as a marker of successful thrombolysis in patients with submassive pulmonary thromboembolism

Pulmonary embolism (PE) is frequently under-diagnosed and associated with high lethality despite progress in prophylaxis and treatment. Aggressive management may improve outcome in patients with high risk of right ventricle (RV) failure secondary to pulmonary hypertension. CT scan angiography, cardiac echo and biomarkers (pro-brain natriuretic peptide (proBNP) and troponin) have been used to identify these high-risk patients. We wanted to evaluate relationship between interventional treatment of acute PE with cardiac biomarkers changes.