Effect of phytoestrogenic constituents of fenugreek in comparison with synthetic estradiol on menopause induced hematological alterations
2017
At menopause the physiological parameters modulated by estrogen are disrupted leading to various symptoms.
Hormone replacement therapy though beneficial has its own drawbacks. Fenugreek seeds, commonly
used in Indian households, is known to possess phytoestrogens. Considering the lack of literature in support
of this, this study was conducted to compare the effects of fenugreek seed extract and 17�-estradiol on
menopause induced alterations in hematological parameters, employing the ovariectomised rat model. Female
Wistar rats, 8 months old were randomly assigned into 4 groups (n = 6): (1) normal control, (2) ovariectomised
and untreated, (3) ovariectomised and treated orally with fenugreek seed extract, (4) ovariectomised and treated
with subcutaneous injections of estradiol. Post-treatment blood samples were collected and various hematological
parameters were analyzed. Fenugreek treated rats showed higher hemoglobin, hematocrit and RBC counts
in comparison to ovariectomised group. Additionally, they showed a higher total leukocyte count (TLC), specifically a higher lymphocyte count than that of control. Estradiol treated groups showed severe leukopenia owing to lymphocytopenia; decreased RBC counts, hemoglobin and hematocrit. However, the changes were statistically significantly only with estradiol treatment. Overall, fenugreek was found to be a better agent to attenuate the menopause induced hematological alterations.
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