A Novel Approach to Detect Therapeutic Resistance in Breast Cancer

Abstract : Purpose/scope: Our aim is to understand whether adjuvant therapy of a first primary breast cancer might predict the prognosis of a metachronous bilateral cancer. Major findings: Our findings support a selection process where adjuvant systemic treatment selectively prevents the occurrence of cancers with a favourable prognosis, allowing those with a more aggressive phenotype to surface clinically. Up-to- date report: We have requested for a no-cost extension of the project due to difficulties with collection of tissue samples.