Ovarian Carcinoma: Quantitative Biexponential MR Imaging Relaxometry Reveals the Dynamic Recruitment of Ferritin-expressing Fibroblasts to the Angiogenic Rim of Tumors

Ferritin heavy chain overexpression in combination with R2 mapping enables quantitative in vivo examination of cell recruitment, and when combined with biexponential MR relaxometry, enables in vivo measurement of reporter gene–expressing cell fraction in a mixed cell population.