Influence of Cytokine Gene Polymorphisms on the Risk of Gastric Disorders in H. pylori Infected Patients

Background and study aim: Helicobacter pylori (H. pylori) is a common organism in developing countries, it causes gastric disorders and cancer. Pathogenesis of these disorders involve cytokine gene polymorphisms that affect cytokine levels and clinical diseases. The aim of the study is to identify the relationship of IL-1β-511, IL-10-519 and TNF-α-308 polymorphisms to the risk of H. pylori infection and occurrence of gastric disorders. Subjects and methods: IL-1β-511, IL-10-519 and TNF-α-308 polymorphisms were assessed using polymerase chain reaction (PCR) restriction fragment length polymorphism technique (RFLP) in 356 subjects classified according to H. pylori infection and gastric disorders. Results: Carriers of T allele of IL-1β-511 and IL-10-519 had increased risk of H. pylori infection (OR:1.95, 95% CI:1.4-2.7, P Conclusion: This study revealed a significant association of the IL-1β -511C/T and IL-10-819C/T but not TNF-α-308 G/A polymorphisms with risk of Helicobacter pylori infection and different gastric diseases in Egyptian patients.