Preparation of Usolic Acid Dropping Pills and Study on its Dissolution in Vitro

Objective To prepare Ursolic Acid Dropping Pills by choosing prescriptions and dropping conditions and to assay its dissolution in vitro.Methods Ursolic Acid Dropping Pills were prepared by dropping method.Optimum prescription and dropping conditions were selected by using spherical degree,weight variation and hardness as comprehensive evaluation indicator.RP-HPLC method was used to determine the content of ursolic acid in dropping pills.Results Optimum prescription and dropping conditions which had been selected were simple and feasible.Ursolic Acid Dropping Pills prepared had good quality and stability,and the method for quality control was accurate.Conclusion Ursolic Acid Dropping Pills had good appearance,little weight variation and accurate content,and its dissolution had been improved significantly.Furthermore,the dissolution rate of Ursolic Acid Dropping Pills in vitro increased 229.2 % and 13.4 % than that of its tablet and capsule within 45 min,respectively.