Protein-Carbohydrate Interactions

Numerous biological processes are dependent on the interaction of proteins with carbohydrates, rendering glycan-binding proteins as potential targets for new medicines. With the rapid growth in genomic data, novel computational methods can be applied to pinpoint putative carbohydrate-binding sites in proteins, for experimental validation. Here, we review the recent developments in the structure and sequence-based protein carbohydrate binding site prediction methods. An attempt has been made to show the developments and the applications for each such method in a chronological order.