Dysbiotic conditions and their management

: The authors present data concerning the role of normal intestinal microflora as a non-specific resistance factor. They systematize the notion of intestinal dysbacteriosis as a clinicolaboratory syndrome, observed in patients with various gastrointestinal pathology, adduce the characteristics of the preparations of probiotics, prebiotics, and synbiotics, and discuss the mechanisms of their action, as well as their efficacy in the management and prevention of microecological disturbances of the intestinal tract. It is recommended that probiotic preparations are administered according to the principle of microecological adequacy, taking into account the condition of the microflora, as well as the phase, stage, and character of the underlying disease. Some preparations should be used for preventive, others--for therapeutic purposes. The authors stress that antibioticotherapy is indicated only in cases of clinically severe infectious process; such therapy should be followed by reestablishment of the normal microflora with proper probiotic preparations.