Effect of Cortex Mori Extract on the Sciatic Nerve Conduction Velocity and Biochemical Function in Diabetic Rats

OBJECTIVE:To probe into the influence of Cortex Mori extract on the sciatic nerve conduction velocity of diabetic rats.METHODS:The diabetic rat model was established by the inducement of alloxan.The diabetic model rats were divided randomly into control group,model group,Cortex Mori extract (high dosage and low dosage)groups and Methycobal treatment group.The intragastric administration was conducted once per day.2 weeks after the administration,the changes of synaptophysin MNCV,SNVC and SL were determined and the tail-flicking test should be undertaken for checking the sensory nerve.RESULTS:Cortex Mori can obviously increase the level of synaptophysin(P0.01 or P0.05),and the sciatic nerve conduction velocity and improve the nerve sensation on diabetic rats(P0.01 or P0.05).Meanwhile,the sensation incubation period was shortened(P0.01 or P0.05).CONCLUSION:Cortex Mori extract has the curative effect for the da_ mage of sciatic nerves of diabetic rats.