Определение адренореактивности организма по адренорецепции клеточной мембраны при сердечно-сосудистой патологии

Scientific studies of cardiovascular diseases' pathogenesis confirmed the leading role of the neurohumoral system regulation imbalance in favour of sympathoadrenal and angiotensinadrenal system hyperactivity. It has been found that there is an unilateral-ity of changes in adrenoreactive features of different body tissues (membrane and cellular structure under influence of catecholamines) and red blood cells. During continuous and intense stimulation with catecholamines decreases the quantity of membrane receptors as well as their functional state changes which presents a manifestation of the general biological phenomenon — cell membrane desensitization. Cause-and-effect relations between catecholamines' activity and /3-АРМ index have been covered in a number of studies, results of which allowed ascertaining the increase of correlation gain between desensitization level and ascending level of excreted adrenaline in blood.