Local prevention of trombosis in animal arteries by means of magnetic targeting of aspirin-loaded red cells

Abstract Trombosis was induced in I8 dog and I6 rabbit arteries by surgically inverting a vascular wall flap into its lumen. A completely occluding red thrombus was formed inside the vessel 4 to 5 hours later in 80% of cases. SmCo5 magnet was secured externally to one of the arteries. The constant magnetic field produced by the magnet had no influence on the clit formation. Autologous red cells loaded with ferromagnetic colloid compound and aspirin were administered intravenously and completely aborted arteriothrombosis on magnet-suplied side with no deterioratory effect on clot formation in the control artery.