Innate Lymphoid Cells: New Targets for Cutaneous Squamous Cell Carcinoma Immunotherapy.

The importance of innate immune cells in cancer promotion has been long recognized. Luci et al. (2021) show a key role for innate lymphoid cells (ILCs) in controlling precancerous skin lesions and impaired function of NK cells and ILC1s during progression to cutaneous squamous cell carcinoma (cSCC). These results, together with other findings, suggest that activation of ILCs could serve as a novel immunotherapeutic strategy against cSCC.