Three-dimensional CBCT images registration method for TMJ based on reconstructed condyle and skull base

Objectives:A method was introduced for three-dimensional (3D) cone-beam computed tomography (CBCT) images registration of temporomandibular joint (TMJ). This study aimed to provide quantitative and qualitative analysis of TMJ bone changes in two-dimensional (2D) and 3D and to provide the technique for computer aided diagnosis of temporomandibular joint disorders (TMD) in the future.Methods:Ten TMJ samples of six patients were obtained from Peking University Hospital of Stomatology. Four of the six patients imaged bilateral TMJs and the other two patients only imaged unilateral TMJ. Each sample consisted of two images from the same TMJ taken at different times. Condyle and skull base were segmented semi-automatically for 3D model reconstruction firstly. Then the segmented condyle and skull base were registered separately. Registration process can be divided into two processes of rough registration and fine registration. Rough registration step was achieved by selecting corresponding points manually and ini...