Use of specific serotonin reuptake inhibitors (SSRIs) (Sertraline or Citalopram) in the treatment of depression reduces the cardiovascular risk in the elderly: Evidence from a Sicilian population >80 years recovered in the assisted sanitary residences (RSA)

Abstract The correlation between depression and cardiovascular pathologies was studied in geriatric age. As a matter of fact, the high comorbidity of depression with the sudden cardiac deaths or other cardiovascular events requires a careful evaluation of these causalities. A total of 110 patients were analyzed, recovered in assisted sanitary residence (from the widely used Italian name: “residenza sanitaria assistita” abbreviated as RSA) during the last 12 months. All patients were above the age of 80 years at the admission (mean age was 83.2 ± 2.8 years), and all of them have had a diagnosis of depression according to the DSM IV. All patients were treated with the antidepressive specific serotonin reuptake inhibitor (SSRI) (Citalopram, 20–40 mg/day, or Sertraline 50–100 mg/day). The patients were divided on the basis of their therapeutic response in two groups: Group A (responders) and Group B (non-responders). After 4, 6 and 12 months of treatment, we observed a reduction of the cardiovascular events (−75%, −83% and −60%, respectively). These findings confirm the existence of a correlation between the level of affectivity and the cardiac functions.