FCT 1-7 : Comparison of sodium thiosulfate solution and mixture of diflucortone valerate and isoconazole nitrate in Malassezia infection

Background: Superficial infection of malassezia occurs in the forms of pityrosporum folliculitis, pityriasis versicolor, seborrheic dermatitis, etc. We can use systemic antifungal agent, topical antifungal agent, zinc pyrithione, urea and so on. Objectives: The purpose of this study is to compare the efficacy and usefulness of mixture of Diflucortone valerate 1mg/g and isoconazole nitrate 10mg/g ointment (Travocort®) and Sodium thiosulfate solution 25%(LST soln.) Methods: We examined 315 patients who diagnosed superficial malassezia infection like pityrosporum folliculitis, pityrosporum versicolor presented to the Department of Dermatology, catholic University Hospital of Daegu between August 2002 and January 2019. Results: Total 315 patients, 124 used Travocort® and 191 used LST soln. The average duration from the beginning to the end of the treatment was 152.33 days for Travocort® and 355.57 days for LST soln. (p = 0.007). Side effects occurred in 20.2% in the Travocort® group and 6.2% in LST soln group. Conclusion: Travocort® has a faster healing rate than LST soln, but the incidence of side effects is higher. This maybe because it acts directly on Malassezia as an antifungal agent, its therapeutic effect is fast. However, its glucocorticoid portion may induce side effects when used for a long time and cause resistancy. Therefore, it may be better regimen to replace Travocort® to another treatment option afterusing for a certain period of time.