Acute ataxic neuropathy with cross‐reactive antibodies to GDlb and GD3 gangliosides

We report a patient with an acute, self-limiting neuropathy consisting of ataxia and areflexia, but without ophthalmoplegia or limb weakness, with transient, high-titer serum IgG antibodies to a single NeuAc(α2–8)NeuAc-linked disialosyl epitope, as found on GD lb and GD 3 gangliosides. The serum did not react with GQ lb , GT la , or GT lb . This atypical case, which most closely represents an incomplete Miller Fisher syndrome, indicates that anti-GD lb /GD s antibodies may be able to induce sensory ataxia.