Phosphorylated (S)-tert-leucinol isophthalic diamide as a ligand for Pd-catalyzed asymmetric allylic substitution

O-Phosphorylation of N,N’-(isophthaloyl)di-(S)-tert-leucinol with (5S)-2-chloro-3-phenyl-1,3-diaza-2-phosphabicyclo[3.3.0]octane afforded bidentate phosphite-type ligand. This ligand provided 93% ee in Pd-catalyzed enantioselective allylation of (E)-1,3-diphenylallyl acetate, and 55% ee in alkylation of cinnamyl acetate with ethyl 2-oxocyclohexane-1-carb-oxylate.