Drug-loaded nanometer anti-adhesion membrane having core/shell structure and preparation method thereof

2014 
The invention provides a drug-loaded nanometer anti-adhesion membrane having a core/shell structure and a preparation method thereof. The drug-loaded nanometer anti-adhesion membrane having the core/shell structure is formed by connecting fibers having the inner core and outer shell structure in parallel, wherein the inner core comprises a therapeutically effective amount of active ingredients and polyvinylpyrrolidone (PVP); the outer shell is polylactic-co-glycolic acid (PLGA) and micropores are formed in the outer shell. The drug-loaded nanometer anti-adhesion membrane having the core/shell structure is simple and efficient in preparation method and inexpensive and the membrane material prepared by the drug-loaded nanometer anti-adhesion membrane has the advantages of controllable specific surface area, controllable pore size, good mechanical properties, blood permeability and controllable biodegradability, no hypersensitivity to a human body during anti-adhesion is caused and the membrane material has affinity with blood and perienchyma in the human body, bio-adhesive surface and no rejection phenomenon.
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