A Review of Cardiac and Non-Cardiac Causes of Troponin Elevation and Clinical Relevance Part II: Non Cardiac Causes

Non cardiac causes of elevated troponins are often overlooked yet elevated troponins have been shown to closely correlate with the prognosis of these conditions The clinical significance of elevated troponins in non cardiac conditions are not completely known Also it is still unclear if these clinical conditions need to be managed differently when they lead to an increase in troponin levels Some of the non cardiac conditions in which elevated troponins are commonly found include pulmonary embolism end stage renal disease Sepsis Systemic inflammatory response syndrome SIRS and critically ill patient rhabdomyolysis physical exercise burns drug toxicity and stroke This article discusses the suggested etiology of elevated cardiac troponins in these conditions and the prognostic values they carry