Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
2020
1H-MR spectroscopy of skeletal muscle provides insight into metabolism that is not
available noninvasively by other methods. The recommendations given in this article
are intended to guide those who have basic experience in general MRS to the special
application of 1H-MRS in skeletal muscle. The highly organized structure of skeletal
muscle leads to effects that change spectral features far beyond simple peak heights,
depending on the type and orientation of the muscle. Specific recommendations are
given for the acquisition of three particular metabolites (intramyocellular lipids,
carnosine and acetylcarnitine) and for preconditioning of experiments and instructions
to study volunteers.
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