Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome.

2020 
Bivalent chromatin domains contain opposing histone modifications that assist cell lineage specification. Two studies report a role for Dppa2 and Dppa4 in the establishment of bivalency and the prevention of de novo DNA methylation at development-related genes in mouse embryonic stem cells.
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