Purity determination of zomepirac sodium dihydrate by high-performance liquid chromatography

A high-performance liquid chromatographic method has been developed to determine the purity of zomepirac sodium dihydrate, a novel non-narcotic analgesic agent. This method is sensitive, reproducible, and accurate. The calibration curves are linear over the range of interest for all the related compounds and impurities. A minimum of 0.1% impurity can be easily detected and quantitated.