The level of GABA in the brain and locomotor behavior

Abstract GABA content was measured in the brains of animals injected with AOAA, DPA or Saline. Significant increases in GABA were found in the motor cortex and cerebellum after treatment with both drugs as compared to saline injected controls. Increased GABA levels were associated with interference with the smooth execution of learned locomotor acts, especially where balancing and coordination of the hind limbs were necessary.