Phosphorylated glycosphingolipids essential for cholesterol mobilization in Caenorhabditis elegans

Sebastian Boland,Ulrike Schmidt,Vyacheslav Zagoriy,Julio L. Sampaio,Raphael F. Fritsche,Regina Czerwonka,Tilo Lübken,Jakob Reimann,Sider Penkov,Hans-Joachim Knölker,Teymuras V. Kurzchalia

Phosphorylated glycosphingolipids essential for cholesterol mobilization in Caenorhabditis elegans

2017

Sebastian Boland
Ulrike Schmidt
Vyacheslav Zagoriy
Julio L. Sampaio
Raphael F. Fritsche
Regina Czerwonka
Tilo Lübken
Jakob Reimann
Sider Penkov
Hans-Joachim Knölker
Teymuras V. Kurzchalia

mmPEGC-C22 is a nonsterol glycolipid involved in early Caenorhabditis elegans larval development that can rescue the growth-arrest phenotype caused by sterol deficiency and is controlled by TGF-β to help mobilize internal sterol pools.

Keywords:

Caenorhabditis elegans
Developmental biology
Molecular biology
Biochemistry
Biology
Glycolipid
Phosphorylation
Mobilization
Sphingolipid
Cell biology
Cholesterol
Sterol
Phenotype

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