Lithium trihydroxy/triisopropoxy-2-pyridylborate salts (LTBS): synthesis, isolation, and use in modified Suzuki–Miyaura cross-coupling reactions
2012
Abstract We describe herein shelf-stable, isolable, and characterizable pyridyl lithium trihydroxy and triisopropoxy 2-borate salts (LTBS) for use in modified Suzuki–Miyaura cross-coupling reactions that can be produced in quantities greater than one hundred grams. Pyridyl LTBS provide a viable cross-coupling alternative to unstable 2-pyridylboronic acids, boronates, and trifluoroborate salt derivatives. We also demonstrate the synthesis and cross-coupling of shelf-stable LTBS reagents of other sp 2 -hybridized nitrogen-containing heterocycles including thiazole, pyrazine, quinoline, and isoquinoline heterocycles.
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