The changes of cyclooxygenase in patients with erosive gastritis treated with Jinghuaweikang

Objective To investigate the therapeutic effect of Jinghuaweikang on patients with erosive gastritis and determine its machanism.Methods Forty patients with erosive gastritis were randomly divided into two groups: Jinghuaweikang group and Sucralfate group.The therapeutic duration was 28 days.The changes of inflammatory grades,expressions of COX-1 and COX-2 in gastric mucosa were investigated.Results Both Jinghuaweikang and Sucralfate could reduce the inflammatory grades of gastric mucosa with similar effects,and there was no significant change for the expression of COX-1 after treatment(P0.05),meanwhile COX-2 expression was decreased(P0.05).Conclusion Jinghuaweikang is effective in patients with erosive gastritis.The machanism correlates with the down-regulation of COX-2 expression.