Experimental and clinical studies of local application of solid and oil bleomycins for the treatment of oral cancer

Summary Local application of solid and oil bleomycins (BLMs) for the treatment of oral cancer was evaluated in experimental and clinical studies. Topical application of the BLMs resulted in high BLM levels in tumour tissues, especially, in metastatic lymph nodes. Clinically, the primary effects of the BLMs were good, and the 3-year end results were very favourable. It is most probable that the use of oil BLM will be included in the treatment plan for metastatic tumours in lymph nodes.