Chryseobacterium meningosepticum infection in intensive care units:an analysis and survey

Objective To understand the clinical characteristics and resistance of Chryseobacterium meningosepticum infection in order to provide evidence for clinical rational drug utilization.Method 47 cases of clinical infections with C.meningosepticum from Jan 2007 to Dec 2008 were performed retrospective analysis.Result 45 cases(95.7%) had critical underlying diseases,the common correlative factor of infection by C.meningosepticum.Other infection-associated factors included invasive operation,environment pollution,central venous catheter and long-term use of broad-spectrum antimicrobial drugs.Metallo-β-lactamases-producing strains accounted for 100% in all C.meningosepticum isolates.C.meningosepticum were susceptible or partly susceptible to vancomycin(100%),cefoperazone/sulbactam(83.0%),piperacillin/tazobactam(57.1%),ticarcillin/clavulanate(52.4%),TMP/SMZ(45.2%).The susceptibility to other antimicrobials tested were within 6.4%-0.Conclusion Decreasing days in hospital,reducing invasive operation and using antibiotics rationally may decrease the risk of infection by C.meningosepticum.Vancomycin,cefoperazone/sulbactam,piperacillin/tazobactam,ticarcillin/clavulanate and TMP/SMZ are the effective antibiotics against C.meningosepticum.