Bone microarchitecture assessed by Trabecular Bone Score is independent of mobility level or height in pediatric patients with cerebral palsy.

: Bone strength and fracture risk do not only depend on bone density, but also on bone structure. The Trabecular Bone Score (TBS) evaluates homogeneity of bone microarchitecture indirectly by measuring gray-level variations of two-dimensional DXA images. Although TBS is well-established for adults, there have been only few publications in pediatrics. In this monocentric retrospective analysis, we investigated TBS in children and adolescents with Cerebral Palsy (CP), a patient group vulnerable to low bone mineral mass due to impaired mobility. The influence of different parameters on TBS and areal BMD (aBMD) were evaluated, as well as the relationship between TBS and aBMD. We compared TBS values of our study population to a reference population. 472 LS-DXA scans of children and adolescents with CP (205 female), aged between 4 and 18 years, were analyzed. The DXA-scans were part of the routine examination. The children had no records of fractures or specific bone diseases. Our study population with CP had similar TBS as the reference population. TBS did not increase with age until an inflection point at 10 (12) years in females (males). Girls had significantly higher TBS than boys (p=0.049) and pubertal girls aged 8-13 years had significantly higher TBS than prepubertal girls (p=0.009). TBS standard deviation score for age (SDS-TBS) and aBMD Z-scores correlated weakly (p<0.001; R=0.276 (males), R=0.284 (females)). Other than for aBMD Z-scores, SDS-TBS was not influenced by age-adjusted height Z-scores and there was no significant difference in SDS-TBS when grouped by mobility levels, using the Gross Motor Function Classification System. Our results indicate for children with CP to have a similar homogeneous distribution of trabecular microarchitecture as controls. Puberty initiation appears to be essential for increase of TBS with age and for sex differences. TBS seems less influenced by body composition, height and mobility than aBMD. This article is protected by copyright. All rights reserved.