Synthesis of 2-phenylimidazo[2,1-b]benzothiazole derivatives as modulators of multidrug resistance for tumor cells
1997
We have investigated 3-substituted-2-phenylimidazo[2,1-b]benzothiazole derivatives and herein we have discussed their pharmaceutical activities. We found that some 2-phenyl-5,6,7,8-tetrahydroimidazo[2,1-b]-benzothiazoles could overcome multidrug resistance for tumor cells. Among them, 2-phenyl-3-(N-methyl-3-piperidyl)carbonylammomiinomemyl-5,6,7,8-tetrahydVoimidazo[2,1-b]benzothiazole [N276-12] demonstrated the most potent activity for overcoming multidrug resistance.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
10
References
6
Citations
NaN
KQI