An integrated transcriptome analysis in T‐cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression

Zahra Haider,Pär Larsson,Mattias Landfors,Linda Köhn,Kjeld Schmiegelow,Trond Flægstad,Jukka Kanerva,Mats Heyman,Magnus Hultdin,Sofie Degerman

An integrated transcriptome analysis in T‐cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression

2019

Zahra Haider
Pär Larsson
Mattias Landfors
Linda Köhn
Kjeld Schmiegelow
Trond Flægstad
Jukka Kanerva
Mats Heyman
Magnus Hultdin
Sofie Degerman

Classification of pediatric T‐cell acute lymphoblastic leukemia (T‐ALL) patients into CIMP (CpG Island Methylator Phenotype) subgroups has the potential to improve current risk stratification. To i ...

Keywords:

Homeobox
TAL1
DNA methylation
Pediatric Acute Lymphoblastic Leukemia
Lymphoblastic Leukemia
Transcriptome
Cancer research
T cell
Biology
Minimal residual disease
Tumor suppressor gene
CpG Island Methylator Phenotype

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