Hypervalent Iodine(III) Reagent-Promoted Rearrangement and Subsequent Oxidative Ring Cleavage of Cyclic 2,3-Epoxy-1-alcohol Derivatives

The rearrangements of 2,3-epoxy alcohol derivatives were achieved using the hypervalent iodine(III) reagent, phenyliodine(III) b:is(trifluoroacetate) (PIFA). In the case of 2,3-epoxy alcohols subsequent oxidative ring cleavage occurred to give ω-formylalkanoic acids.