Urate Oxidase Purification by Salting-in Crystallization: Towards an Alternative to Chromatography

Competing Interests: Francois Ragot, Mohamed El Hajji and Bertrand Castro are employees of Sanofi-Aventis. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. Funding: Sanofi-Aventis (France) supported this work with contract n°006978 (2006–2009) for a PhD thesis. Francois Ragot, Mohamed El Hajji and Bertrand Castro are employees of Sanofi-Aventis, which supplied the protein for the study, organized regular meetings and reports during the three PhD thesis years, validated study design, data collection and analysis. They accepted the decision to publish and participated in the writing of the manuscript.