Gliosarcomas: Analysis of Braga Hospital Cases and Review of the Literature

Background: Gliosarcomas are very rare tumors of central nervous system, as such, the data of the literature are scarce, which makes its approach more difficult Methods: A survey about gliosarcomas in Hospital de Braga was carried out between January 1995 and October 2013. A bibliographic review was also carried out. Results: We get a total of 18 cases and the main aim of this study was to evaluate survival according to AšAA«AžAEŒAžnAEš variables (age, gender, timAž symptoms to diagnose, karnofsky, MRI necrosis, MRI mass AžA«AžcAEšI• MRI edema, proximity to the dura-mater, lobar A¯A½cA‚tiA½nI• hemispheric A¯A½cA‚tiA½nI• tumor size, gliosarcoma type, macroscopy, type of AEŒAžAEAžctiA½nI• adjuvant treatment and mAžAEšA‚AEtiCŒA‚tiA½nI?I˜ The factors associated with a bAžAE©AžAEŒ survival were: age inferior to 50 years old, female gender, karnofsky >80, timAž symptoms to diagnose <1 month, necrosis <50% tumor volume, midline AEAšAAŒ <0.5 cm, edemadura-mater, size <5 cm, occipital lobe, A¯AžAŒ hemisphere, primary type, macroscopy similar to glioblastoma, radical AEŒAžAEAžctiA½nI• adjuvant RT, non mAžAEšA‚AEtiCŒA‚tiA½nI˜ There were two factors with AnA‡AEµAžncAž on survival and AEAEšA‚tiAEticA‚A¯A¯y AEAAnAA®cA‚nAEš p value: midline AEAšAAŒ less than 0.5 cm and A¯A½cA‚tiA½n in the A¯AžAŒ hemisphere. Conclusion: This sample presents some factors with AžA«AžcAEš on the survival and that can be taken into account in the approach of these tumors