The association between rosacea and the condition of low-tolerance to skincare of the facial skin: a case-control study in China.

Background Patients with rosacea often complained of low-tolerance to skincare. Aim To examine if the preexisted low-tolerance to skincare is associated with rosacea the occurrence of the Chinese population. Methods A retrospective case-control survey of 997 rosacea cases and 1,012 skin-healthy controls was carried out in China. Low-tolerance to skincare was evaluated based on the history of facial skin allergic reactions related to skincare in the past five years before the onset of rosacea. A comparative analysis was performed between the case and control groups by the chi-square test and the logistic regression analysis. Results History of facial skin allergic reaction due to skin care products (OR=5.110, 95%CI=3.893-6.706) and skin care in beauty salons (OR=3.002, 95%CI=1.506-5.981) both presented a positive correlations with the occurrence of rosacea. Facial masks and cosmetics were two of the most common products causing facial allergic reaction. The OR values increased with the increased frequency of allergic reactions related to facial mask and cosmetics. In addition, the history of facial skin allergic reaction had a significantly associated with the severity of self-reported symptoms of rosacea including dryness, burning, stinging and itching. Conclusions The condition of low-tolerance of the facial skin to skincare was closely associated with the occurrence of rosacea.