Galectin-1 confers immune privilege to human trophoblast: implications in recurrent fetal loss

Rosanna E Ramhorst2, Laura Giribaldi3,4, Laura Fraccaroli2, Marta AToscano4, Juan C Stupirski4, Marta D Romero5, Edith S Durand6, Natalia Rubinstein7, Astrid Blaschitz8, Peter Sedlmayr8, Susana GentiRaimondi9, Leonardo Fainboim10, and Gabriel A Rabinovich1,3,4 Laboratory of Immunopharmacology; and Laboratory of Functional Glycomics, Department of Biological Chemistry, Faculty of Exact and Natural Sciences, University of Buenos Aires, C1428 Buenos Aires, Argentina; Laboratory of Immunopathology, Institute of Biology and Experimental Medicine (IBYME), National Council Research (CONICET), C1428 Buenos Aires, Argentina; Laboratory of Clinical Immunopathology, LIIDO; and Department of Biological Chemistry, Faculty of Chemical Sciences, National University of Cordoba and Center of Investigation in Biological Chemistry of Cordoba (CIQUIBIC), National Council Research (CONICET), C5000 Cordoba, Argentina; Faculty of Exact and Natural Sciences, Institute of Physiology, Molecular Biology and Neuroscience (IFIBYNE), National Council Research (CONICET), University of Buenos Aires, C1428 Buenos Aires, Argentina; Center for Molecular Medicine, Institute of Cell Biology, Histology and Embryology, Medical University of Graz, 8010 Graz, Austria; Department of Clinical Biochemistry, Faculty of Chemical Sciences, National University of Cordoba and Center of Investigation in Clinical Biochemistry and Immunology (CIBICI), National Council Research (CONICET), C5000 Cordoba, Argentina; and Division of Immunogenetics, Hospital de Clinicas “Jose de San Martin”, University of Buenos Aires, C1120 Buenos Aires, Argentina