Inherently fluorescent and porous zirconiacolloids : preparation, characterization and drugadsorption studies
2015
Porous, fluorescent zirconia particles of nearly 380 nm diameter were prepared without template molecules
or labeling dyes. The porous structure is the result of aggregation-induced particle formation. The inherent
fluorescence is assigned to coordinatively unsaturated Zr4+ ions at the sol–gel derived ZrO2 surface. After
physico-chemical characterization of the native zirconia particles carboxyl and/or amine bearing drug molecules
(D,L-a-difluoromethylornithine – DFMO, ursolic acid – UA and doxorubicin – DOX) were adsorbed
onto their surface, and the products were analyzed with Fourier-transform infrared spectroscopy (FTIR),
thermogravimetry (TG), small-angle X-ray scattering (SAXS), fluorimetry and zeta potential vs. pH measurements.
We have found that DOX complexes coordinatively unsaturated Zr4+ ions without dislocating them,
while carboxyl-bearing drugs interact with basic surface Zr–OH sites eliminating some of the carbonate
species. The adsorption of UA at the zirconia surface shifts considerably the isoelectric point of the surface
and thus provides kinetic stability to the particles at physiological pH. An in vivo biodistribution study in
two healthy dogs performed by SPECT/CT detection after 99mTc labeling of the nanocarriers has shown
the possibility of drug delivery application.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI